期刊
EMBO JOURNAL
卷 34, 期 16, 页码 2198-2210出版社
WILEY
DOI: 10.15252/embj.201591163
关键词
adaptor protein; compatibility groups; T6SS; type VI secretion system; Vibrio cholerae
资金
- Canadian Institutes of Health Research Operating Grant [MOP-84473, MOP-137106]
- Alberta Innovates Health Solutions
- Graduate Student Scholarship from Alberta Innovates Health Solutions
- German National Academic Foundation
- CIHR's Canadian Graduate Scholarship-Master's Award
- RISE Program of German Academic Exchange Service
Vibrio cholerae is a diverse species of Gram-negative bacteria, commonly found in the aquatic environment and the causative agent of the potentially deadly disease cholera. These bacteria employ a type VI secretion system (T6SS) when they encounter prokaryotic and eukaryotic competitors. This contractile puncturing device translocates a set of effector proteins into neighboring cells. Translocated effectors are toxic unless the targeted cell produces immunity proteins that bind and deactivate incoming effectors. Comparison of multiple V. cholerae strains indicates that effectors are encoded in T6SS effector modules on mobile genetic elements. We identified a diverse group of chimeric T6SS adaptor proteins required for the translocation of diverse effectors encoded in modules. An example for a T6SS effector that requires T6SS adaptor protein 1 (Tap-1) is TseL found in pandemic V. cholerae O1 serogroup strains and other clinical isolates. We propose a model in which Tap-1 is required for loading TseL onto the secretion apparatus. After T6SS-mediated TseL export is completed, Tap-1 is retained in the bacterial cell to load other T6SS machines.
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