Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population

Objective: The aim of the study was to estimate breast cancer risk conferred by individual single-nucleotide polymorphisms of breast cancer susceptibility genes. Methods: We analyzed the 48 tagging single-nucleotide polymorphisms of 8 breast cancer susceptibility genes involved in the monoubiquitinated FANCD2-DNA damage repair pathway in 734 Chinese women with breast cancer and 672 age-matched healthy controls. Results: Forty-five tagging single-nucleotide polymorphisms were successfully geno-typed by SNPscan, and the call rates for each tagging single-nucleotide polymorphisms were above 98.9%. We found that 13 tagging single-nucleotide polymorphisms of 5 genes (Patter and localizer of Breast cancer gene2 (PALB2), Tumour protein 53 (TP53), Nijmegen breakage syndrome 1, Phosphatase and tensin homolog deleted from chromosome 1 0 (PTEN), and Breast cancer gene 1 (BRCA 1-interacting protein 1)) were significantly associated with breast cancer risk. A total of 5 tagging single-nucleotide polymorphisms (rs229994 1 of PTEN, rs2735385, rs6999227, rsI805812, and rsI061302 of Nijmegen breakage syndrome 1) were tightly associated with breast cancer risk in sporadic cases, and 5 other tagging single-nucleotide polymorphisms (rs 1042522 of TP53, rs2735343 of PTEN, rs7220719, rs 16945628, and rs11871753 of BRCA 1 -interacting protein 1) were tightly associated with breast cancer risk in familial and early-onset cases. Conclusions: Some of the tagging single-nucleotide polymorphisms of 5 genes (PALB2, TPS3, Nijmegen breakage syndrome I PTEN, and BRCA 1 -interacting protein 1) involved in the monoubiquitinated FANCD2-DNA damage repair pathway were significantly associated with breast cancer risk.