期刊
NEUROIMAGE
卷 148, 期 -, 页码 115-122出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2017.01.007
关键词
Brain iron; Alcohol use disorder; Quantitative susceptibility mapping; Deep grey matter; Echo-planar imaging; Resting state fMRI
资金
- Canadian Institutes of Health Research [NRF 110026]
- European Commission under ERANet Neuron initiative (TRANSALC FKZ) [01EW1112]
- Natural Sciences and Engineering Research Council (Postgraduate Graduate Scholarship - Doctoral) [PGSD2-475687-2015]
- Alberta Innovates: Health Solutions (Graduate Studentship) [201500246]
- University of Alberta (President's Doctoral Prize of Distinction)
- Alberta Innovates [201500246] Funding Source: researchfish
Purpose: Evaluate brain iron accumulation in alcohol use disorder (AUD) patients compared to controls using quantitative susceptibility mapping (QSM). Methods: QSM was performed retrospectively by using phase images from resting state functional magnetic resonance imaging (fMRI). 20 male AUD patients and 15 matched healthy controls were examined. Susceptibility values were manually traced in deep grey matter regions including caudate nucleus, combined putamen and globus pallidus, combined substantia nigra and red nucleus, dentate nucleus, and a reference white matter region in the internal capsule. Average susceptibility values from each region were compared between the patients and controls. The relationship between age and susceptibility was also explored. Results: The AUD group exhibited increased susceptibility in caudate nucleus (+8.5%, p=0.034), combined putamen and globus pallidus (+10.8%, p=0.006), and dentate nucleus (+14.9%, p=0.022). Susceptibility increased with age in two of the four measured regions - combined putamen and globus pallidus (p=0.013) and combined substantia nigra and red nucleus (p=0.041). AUD did not significantly modulate the rate of susceptibility increase with age in our data. Conclusion: Retrospective QSM computed from standard fMRI datasets provides new opportunities for brain iron studies in psychiatry. Substantially elevated brain iron was found in AUD subjects in the basal ganglia and dentate nucleus. This was the first human AUD brain iron study and the first retrospective clinical fMRI QSM study.
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