期刊
NEW JOURNAL OF CHEMISTRY
卷 42, 期 24, 页码 19720-19728出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj04867c
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资金
- National Natural Science Foundation of China [21502135]
- Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi [201802024]
A chemoselective phosphine-catalyzed cyanoacylation of alpha-dicarbonyl compounds is reported. Under the catalysis of P(NMe2)(3), the cyanoacylation of alpha-dicarbonyl compounds such as isatins, alpha-keto esters, and alpha-diketones with acyl cyanides exclusively proceeds under very mild conditions, affording a wide range of cyanohydrin esters bearing one quaternary stereocenter in moderate to excellent yields. It represents the first phosphine-catalyzed cyanoacylation of alpha-dicarbonyl compounds and also provides a general method to prepare fully substituted cyanohydrin esters.
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