期刊
EUROPEAN SURGICAL RESEARCH
卷 59, 期 5-6, 页码 361-370出版社
KARGER
DOI: 10.1159/000494832
关键词
Colorectal cancer; Cancer genetics; Lymph node metastasis; Intratumor heterogeneity
类别
资金
- American Surgical Association Foundation Fellowships [5P50CA130810]
- John S. and Suzanne C. Munn Cancer Research Fund [5P30A046592]
- National Cancer Institute [K08CA190645]
Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy. (c) 2018 S. Karger AG, Basel
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