期刊
NEUROENDOCRINOLOGY
卷 106, 期 3, 页码 234-241出版社
KARGER
DOI: 10.1159/000477849
关键词
Cystic pancreatic neuroendocrine tumors; Solid pancreatic neuroendocrine tumors; Single-center surgical series; Clinical features; Postoperative outcome
资金
- Italian Cancer Genome Project - Ministry of University [FIRB RBAP-10AHJB]
- Associazione Italiana Ricerca Cancro [12182]
- FP7 European Community Grant Cam-Pac [602783]
- Italian Ministry of Health [FIMP-CUP_J33G13000210001]
Introduction: Cystic pancreatic neuroendocrine tumors (CPanNETs) represent an uncommon variant of pancreatic neuroendocrine tumors (PanNETs). Due to their rarity, there is a lack of knowledge with regard to clinical features and postoperative outcome. Methods: The prospectively maintained surgical database of a high-volume institution was queried, and 46 resected CPanNETs were detected from 1988 to 2015. Clinical, demographic, and pathological features and survival outcomes of CPanNETs were described and matched with a population of 92 solid PanNETs (SPanNETs) for comparison. Results: CPanNETs accounted for 7.8% of the overall number of resected PanNETs (46/587). CPanNETs were mostly sporadic (n = 42, 91%) and nonfunctioning (39%). Two functioning CPanNETs were detected (4.3%), and they were 2 gastrinomas. The median tumor diameter was 30 mm (range 10-120). All tumors were well differentiated, with 38 (82.6%) G1 and 8 (17.4%) G2 tumors. Overall, no CPanNET showed a Ki-67 > 5%. A correct preoperative diagnosis of a CPanNET was made in half of the cases. After a median follow-up of > 70 months, the 5- and 10-year overall survival of resected CPanNETs was 93.8 and 62.5%, respectively, compared to 92.7 and 84.6% for SPanNETs (p > 0.05). The 5-and 10-year disease-free survival rates were 94.5 and 88.2% for CPanNETs and 81.8 and 78.9% for SPanNETs, respectively (p > 0.05). Conclusion: In the setting of a surgical cohort, CPanNETs are rare, nonfunctional, and well-differentiated neoplasms. After surgical resection, they share the excellent outcome of their well-differentiated solid counterparts for both survival and recurrence. (c) 2017 S. Karger AG, Basel
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