期刊
NEURODEGENERATIVE DISEASES
卷 17, 期 4-5, 页码 208-212出版社
KARGER
DOI: 10.1159/000464445
关键词
Ataxia; SLC25A46; Mutation; North Africa
资金
- Intramural Research Programs of the National Institute on Aging
- National Institutes of Neurological Disorders and Stroke (within the National Institutes of Health, Department of Health and Human Services) [ZO1 AG000958]
- National Ataxia Foundation
Background: Autosomal recessive cerebellar ataxias (ARCA) are a complex group of neurodegenerative disorders with high clinical and genetic heterogeneity. In most cases, the cerebellar ataxia is not pure, and complicating clinical features such as pyramidal signs or extraneurological features are found. Objective: To identify the genetic origin of the cerebellar ataxia for 3 consanguineous North African families presenting with ARCA. Methods: Genome-wide high-density SNP genotyping and whole-exome sequencing were performed followed by Sanger sequencing for mutation confirmation. Results: Two variants were identified in SLC25A46. Mutations in this gene have been previously associated with Charcot-Marie-Tooth type 2 and optic atrophy. While the previously reported variant p. Arg340Cys seems to be consistently associated with the same clinical features such as childhood onset, optic atrophy, gait and speech difficulties, and wasting of the lower limbs, the patient with the novel mutation p. Trp160Ser did not present with optic atrophy and his ocular abnormalities were limited to nystagmus and saccadic pursuit. Conclusion: In this study, we report a novel variant (p. Trp160Ser) in SLC25A46 and we broaden the phenotypic spectrum associated with mutations in SLC25A46. (C) 2017 S. Karger AG, Basel
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