期刊
NEUROBIOLOGY OF DISEASE
卷 97, 期 -, 页码 119-126出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2016.07.010
关键词
Neurotrophic factors; Neurotrophins; Depression; Anxiety; BDNF
资金
- ERC [322742 - iPLASTICITY]
- Sigrid Juselius Foundation and Academy of Finland [257486]
- Ministry of Education, Culture, Sports, Science and Technology of Japan [40344171]
- Japan Science and Technology Agency
- Core Research for Evolutional Science and Technology
- Academy of Finland (AKA) [257486, 257486] Funding Source: Academy of Finland (AKA)
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings have shown that posttranslational processing of BDNF gene product can yield different molecular entities that differently influence signaling through BNDF receptor TrkB and the pan-neurotrophin receptor p75(NTR). We will here review these data and discuss new insights into the possible pathophysiological roles of those new BDNF subtypes as well as recent findings on the role of BDNF mediated neuronal plasticity in mood disorders and their treatments. (C) 2016 Elsevier Inc All rights reserved.
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