期刊
NEUROBIOLOGY OF AGING
卷 49, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.10.002
关键词
APOE; REM sleep behavior disorder; Genetics; Parkinson's disease; Dementia with Lewy bodies
资金
- Michael J. Fox Foundation
- INSERM
- Monument Trust Discovery Award from Parkinson's UK
- National Institute for Health Research, Oxford Biomedical Research Centre based at Oxford University Hospitals
- Dementias and Neurodegenerative Diseases Research Network (DeNDRoN)
- Weston Brain Institute
- J. L. Levesque Foundation
- Lowensteinstiftung
- German Ministry of Education and Science (BMBF)
- Novartis pharma
- Jazz Pharmaceuticals
- Biron soins du sommeil
- Merck
- GlaxoSmithKline
- UCB
- NHS Trustof
- University Oxford
- Canada Research Chair on Cognitive Decline in Pathological Aging
- Canada Research Chair in Genetics of the Nervous System
- Wilder Penfield Chair in Neurosciences
- Parkinson's UK [J-0901, J-1403] Funding Source: researchfish
The present study aimed to examine whether the APOE epsilon 4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE epsilon 4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE epsilon 4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy ( 0.14, p = 1.0). The APOE epsilon 4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies. (C) 2016 Elsevier Inc. All rights reserved.
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