期刊
BMB REPORTS
卷 51, 期 12, 页码 648-653出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2018.51.12.205
关键词
Biomarker; Cell growth; Lung adenocarcinoma; Metastasis; SPINK1
资金
- Science Technology Department of Zhejiang Province of China [LGF18H160008, 2015C37024, 2017C37047]
- Bureau of Science and Technology of Zhoushan [2014C31065, 2016C13037]
- Bureau of Health and family planning of Zhoushan [2017G02]
Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metallo-proteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAO tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12.
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