期刊
NEUROBIOLOGY OF AGING
卷 52, 期 -, 页码 98-105出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.12.028
关键词
Aging; Microglia activation; Neurodegeneration; Neuroinflammation; Neuropathology; Hippocampus; Alzheimer's disease; Traumatic brain injury
资金
- National Institutes of Health [P30 AG028383, R00 AG044445]
A subtype of microglia is defined by the morphological appearance of the cells as rod shaped. Little is known about this intriguing cell type, as there are only a few case reports describing rod-shaped microglia in the neuropathological literature. Rod-shaped microglia were shown recently to account for a substantial proportion of the microglia cells in the hippocampus of both demented and cognitively intact aged individuals. We hypothesized that aging could be a defining feature in the occurrence of rodshaped microglia. To test this hypothesis, 2 independent series of autopsy cases (total n 168 cases), which covered the adult lifespan from 20 to 100_ years old, were included in the study. The presence or absence of rod-shaped microglia was scored on IBA1 immunohistochemically stained slides for the hippocampus and cortex. We found that age was one of the strongest determinants for the presence of rod-shaped microglia in the hippocampus and the cortex. We found no association with the presence of rod-shaped microglia and a self-reported history of a TBI. Alzheimer's diseaseerelated pathology was found to influence the presence of rod-shaped microglia, but only in the parietal cortex and not in the hippocampus or temporal cortex. Future studies are warranted to determine the functional relevance of rod-shaped microglia in supporting the health of neurons in the aged brain, and the signaling processes that regulate the formation of rod-shaped microglia. (C) 2017 Elsevier Inc. All rights reserved.
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