期刊
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
卷 11, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1756284818811294
关键词
cirrhosis; hepatic hemodynamic; HVPG; portal pressure; sinusoid
资金
- Stiftung fur Leberkrankheiten
- Asociacion Espanola Para el Estudio del Higado
- Instituto de Salud Carlos III [CD15/00050, FIS PI17/00012]
- Spanish Ministry of Science, Innovation and Universities, Centro de Investigacion Biomedica en Red en Enfermedades Hepaticas y Digestivas (CIBEREHD)
- European Union Funds FEDER 'una manera de hacer Europa'
Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated by a paradoxical increase in portal blood inflow. Although extensive preclinical and clinical research in the field has been developed in recent decades, no effective treatment targeting its primary mechanism has been defined. The present review critically summarizes the current knowledge in portal hypertension therapeutics, focusing on those strategies driven by the disease pathophysiology and underlying cellular mechanisms.
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