期刊
LIFE SCIENCE ALLIANCE
卷 1, 期 5, 页码 -出版社
LIFE SCIENCE ALLIANCE LLC
DOI: 10.26508/lsa.201800111
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资金
- National Institute of Allergy and Infectious Diseases [AI123613]
- Johns Hopkins Malaria Research Institute
- Bloomberg Philanthropies
- National Institutes of Health [RR00052]
- NIGMS [P41-GM103311]
Plasmodium sporozoite liver infection is an essential step for parasite development in its mammalian host. Previously, we used a phage display library to identify mimotope peptides that bind to Kupffer cells and competitively inhibit sporozoite-Kupffer cell interaction. These peptides led to the identification of a Kupffer cell receptor-CD68-and a Plasmodium sporozoite ligand-GAPDH-that are required for sporozoite traversal of Kupffer cells and subsequent infection of hepatocytes. Here, we report that the C-terminal end of Plasmodium GAPDH interacts with the Kupffer CD68 receptor, and identify two epitopes within this region as candidate antigens for the development of antibodies that inhibit Plasmodium infection.
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