期刊
BIO-PROTOCOL
卷 8, 期 6, 页码 -出版社
BIO-PROTOCOL
DOI: 10.21769/BioProtoc.2777
关键词
Mouse pain model; SNI surgery; Peripheral nerve injury; Sciatic nerve; Neuropathic pain
类别
资金
- National Institutes of Health [R01GM107469, R21NS106469]
Experimental models of peripheral nerve injury have been developed to study mechanisms of neuropathic pain in living animals. The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve. SNI-operated mice require less force applied to the affected limb to elicit a withdrawal behavior as compared to sham mice. This effect is observed as early as 2 days after surgery and lasts for at least 1 month. We describe detailed surgical procedures to establish the SNI mouse model that has been widely used for investigating mechanisms of neuropathic pain.
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