期刊
SYNOPEN
卷 2, 期 1, 页码 41-49出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1591933
关键词
cyclopropanes; enantioselectivity; Grignard reagents; nitriles; spiro compounds; titanium
资金
- Ministere de l'enseignement superieur et de la recherche
- Region Pays-de-la-Loire
- Centre National de la Recherche Scientifique
The titanium-catalyzed asymmetric cyclopropanation of cyanoesters with Grignard reagents was investigated for the first time. Particularly, the study of the efficiency of Taddol-based titanium complexes has shown that the prior preparation of Taddol titanium complexes was not required and a large panel of ligands was evaluated by using this approach. The spirocyclopropanelactams were obtained with good diastereoselectivity and with moderate enantioselectivities from the main diastereoisomer (up to 32%).
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