期刊
NEURAL REGENERATION RESEARCH
卷 12, 期 8, 页码 1197-1209出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.213532
关键词
light-activated proteins; neural plasticity; spinal cord injury; epilepsy; Parkinson's disease; Alzheimer's disease; multiple sclerosis; neural engineering; memory retrieval; neuron inhibition; neuron activation; neural regeneration
资金
- NIH [NS059622, NS073636]
- DOD CDMRP [W81XWH-12-1-0562]
- U.S. Department of Veterans Affairs [I01 BX002356]
- Craig H Neilsen Foundation [296749]
- Indiana Spinal Cord and Brain Injury Research Foundation (ISCBIRF) [019919]
- Mari Hulman George Endowment Funds
Neural degeneration and regeneration are important topics in neurological diseases. There are limited options for therapeutic interventions in neurological diseases that provide simultaneous spatial and temporal control of neurons. This drawback increases side effects due to non-specific targeting. Optogenetics is a technology that allows precise spatial and temporal control of cells. Therefore, this technique has high potential as a therapeutic strategy for neurological diseases. Even though the application of optogenetics in understanding brain functional organization and complex behaviour states have been elaborated, reviews of its therapeutic potential especially in neurodegeneration and regeneration are still limited. This short review presents representative work in optogenetics in disease models such as spinal cord injury, multiple sclerosis, epilepsy, Alzheimer's disease and Parkinson's disease. It is aimed to provide a broader perspective on optogenetic therapeutic potential in neurodegeneration and neural regeneration.
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