期刊
NEURAL REGENERATION RESEARCH
卷 12, 期 4, 页码 549-557出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.205084
关键词
BDNF; CDNF; GDNF; NGF; neurodegenerative diseases; treatment
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Programa de Apoio aos Nucleos de Excelencia (PRONEX)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Fundacao de Apoio a Pesquisa do Estado de Santa Catarina (FAPESC)
- FINEP (Financiadora de Estudos e Projetos)
- INCT (Instituto Nacional de Ciencia e Tecnologia)
Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has been extensively investigated into the context of neurodegenerative diseases. Alzheimer's disease and Parkinson's disease show changes in the regulation of specific neurotrophic factors and their receptors, which appear to be critical for neuronal degeneration. Indeed, neurotrophic factors prevent cell death in degenerative processes and can enhance the growth and function of affected neurons in these disorders. Based on recent reports, this review discusses the main findings related to the neurotrophic factor support u mainly brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor u in the survival, proliferation and maturation of affected neurons in Alzheimer's disease and Parkinson's disease as well as their putative application as new therapeutic approach for these diseases management.
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