期刊
NEURAL REGENERATION RESEARCH
卷 12, 期 6, 页码 881-885出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.208544
关键词
adenosine; aquaporin; astrocyte; BDNF; calcium channel; epilepsy; psychiatric disorder
资金
- Grants-in-Aid for Scientific Research [26430071, 17K07110] Funding Source: KAKEN
Adenosine modulates diverse physiological and pathological processes in the brain, including neuronal activities, blood flow, and inflammation. However, the mechanisms underlying the dynamics of extracellular adenosine are not fully understood. We have recently developed a novel biosensor, called an adenosine sensor cell, and we have characterized the neuronal and astrocytic pathways for elevating extracellular adenosine. In this review, the physiological implications and therapeutic potential of the pathways revealed by the adenosine sensor cells are discussed. We propose that the multiple pathways regulating extracellular adenosine allow for the diverse functions of this neuromodulator, and their malfunctions cause various neurological and psychiatric disorders.
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