期刊
NEURAL REGENERATION RESEARCH
卷 12, 期 7, 页码 1103-1110出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.211189
关键词
nerve regeneration; human Wharton's jelly-derived mesenchymal stem cells; ischemic stroke; cell transplantation; middle cerebral artery occlusion; neural differentiation; neurological function; neural regeneration
资金
- National Natural Science Foundation of China [31171038]
- Natural Science Foundation of Jiangsu Province of China [BK2011385]
- 333 Program Funding of Jiangsu Province of China [BRA2016450]
- Training Program of Innovation and Entrepreneurship for Undergraduates of Nantong University of China [201510304033Z, 201610304053Z]
- Training Program of Innovation and Entrepreneurship for Graduates of Nantong University of China [YKC14050, YKC15046]
- Funds for the Priority Academic Program Development of Jiangsu Higher Education Institutions of China
Human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have excellent proliferative ability, differentiation ability, low immunogenicity, and can be easily obtained. However, there are few studies on their application in the treatment of ischemic stroke, therefore their therapeutic effect requires further verification. In this study, hWJ-MSCs We re transplanted into an ischemic stroke rat model via the tail vein 48 hours after transient middle cerebral artery occlusion After 4 weeks, neurological functions of the rats implanted with hWJ-MSCs were significantly recovered. Furthermore, many hWJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron like cells at this region. These results confirm that hWJ-MSCs transplanted into the ischemic stroke rat can differentiate into neuron-like cells to improve rat neurological function and behavior.
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