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Colin W. Garvie et al.
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Evan A. Stein et al.
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Calcium-Independent Inhibition of PCSK9 by Affinity-Improved Variants of the LDL Receptor EGF(A) Domain
Yingnan Zhang et al.
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Nabil G. Seidah et al.
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Data processing and analysis with the autoPROC toolbox
Clemens Vonrhein et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov et al.
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Overview of the CCP4 suite and current developments
Martyn D. Winn et al.
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XDS
Wolfgang Kabsch
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Features and development of Coot
P. Emsley et al.
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PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
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Lianming Liang et al.
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Matthew J. Bottomley et al.
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Molecular basis for LDL receptor recognition by PCSK9
Hyock Joo Kwon et al.
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The self-inhibited structure of full-length PCSK9 at 1.9 Å reveals structural homology with resistin within the C-terminal domain
Eric N. Hampton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity
Jun Li et al.
BIOCHEMICAL JOURNAL (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
Markey C. McNutt et al.
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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation
Da-Wei Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
David Cunningham et al.
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Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library
We-Ching Liang et al.
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Raffi Tonikian et al.
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
JC Cohen et al.
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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
Kerry Zobel et al.
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SA Andronati et al.
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High-affinity human antibodies from phage-displayed synthetic fab libraries with a single framework scaffold
CV Lee et al.
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CV Lee et al.
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MC Franklin et al.
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S Henrich et al.
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel et al.
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Structure of a serine protease proteinase K from Tritirachium album limber at 0.98 Å resolution
C Betzel et al.
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