期刊
CURRENT CLINICAL MICROBIOLOGY REPORTS
卷 5, 期 3, 页码 181-189出版社
SPRINGER
DOI: 10.1007/s40588-018-0098-6
关键词
Neutrophils; Recruitment; Effector function; Fungal killing; Candida; Aspergillus
类别
资金
- Division of Intramural Research, NIAID, NIH
Purpose of Review Invasive fungal infections caused by the commensal yeast Candida and the ubiquitous. inhaled mold Aspergillus have emerged as major causes of morbidity and mortality in critically ill and immunosuppressed patient populations. Here, we review how neutrophils contribute to effective immunity against these infections. Recent Findings Studies in mouse models of invasive candidiasis and aspergillosis and observations in hematological patients with chemotherapy-induced neutropenia and in patients with primary immunodeficiency disorders that manifest with these infections have highlighted the critical role of neutrophils and have identified key immune factors that promote neutrophil-mediated effective host defense against invasive fungal disease. Summary Neutrophils are crucial in host protection against invasive candidiasis and aspergillosis. Recent advances in our understanding of the molecular cues that mediate protective neutrophil recruitment and effector function against these infections hold promise for developing immune-based strategies to improve the outcomes of affected patients.
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