期刊
NATURE REVIEWS NEUROSCIENCE
卷 18, 期 3, 页码 131-146出版社
NATURE PORTFOLIO
DOI: 10.1038/nrn.2016.182
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资金
- National Institute of Health Research Cambridge Biomedical Research Centre
- National Institute for Health Research [NF-SI-0513-10051] Funding Source: researchfish
Defining the organizational principles of neuronal networks at the cellular scale, or micro-connectomics, is a key challenge of modern neuroscience. In this Review, we focus on graph theoretical parameters of micro-connectome topology, often informed by economical principles that conceptually originated with Ramon y Cajal's conservation laws. First, we summarize results from studies in intact small organisms and in samples from larger nervous systems. We then evaluate the evidence for an economical trade-off between biological cost and functional value in the organization of neuronal networks. Various results suggest that many aspects of neuronal network organization are indeed the outcome of competition between these two fundamental selection pressures.
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