期刊
NATURE REVIEWS NEUROSCIENCE
卷 18, 期 6, 页码 362-374出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2017.42
关键词
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资金
- National Institute on Aging [AG037457, AG047902]
- American Sleep Medicine Foundation
- Glenn Foundation for Medical Research
- National Institutes of Health
- Grants-in-Aid for Scientific Research [17H07417] Funding Source: KAKEN
In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both in the brain and at the 'systemic' level. CNS decline drives the progressive impairment of cognitive, social and physical abilities, and the mechanisms underlying CNS regulation of the ageing process, such as microglia-neuron networks and the activities of sirtuins, a class of NAD+-dependent deacylases, are beginning to be understood. Such mechanisms are potential targets for the prevention or treatment of age-associated dysfunction and for the extension of a healthy lifespan.
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