期刊
NATURE REVIEWS NEUROSCIENCE
卷 18, 期 8, 页码 459-469出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2017.71
关键词
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资金
- Genentech Foundation Predoctoral Fellowship
- University of California San Francisco (UCSF) Discovery Fellowship
- US National Science Foundation Graduate Research Fellowship [1144247]
- Achievement Rewards for College Scientists (ARCS) Foundation Scholarship
- UCSF Discovery Fellowship
- US National Institutes of Health (NIH) [F31-HL131463]
- NYSCF
- American Diabetes Association Pathway Program
- Rita Allen Foundation
- McKnight Foundation
- Alfred P. Sloan Foundation
- Brain & Behavior Research Foundation
- Esther A. & Joseph Klingenstein Foundation
- Program for Breakthrough Biological Research
- UCSF Diabetes and Endocrinology Research Center [P30-DK06372]
- Nutrition and Obesity Research Center [P30-DK098722]
- NIH Director's New Innovator Award [DP2-DK109533, R01-NS094781, R01-DK106399]
Thirst motivates animals to find and consume water. More than 40 years ago, a set of interconnected brain structures known as the lamina terminalis was shown to govern thirst. However, owing to the anatomical complexity of these brain regions, the structure and dynamics of their underlying neural circuitry have remained obscure. Recently, the emergence of new tools for neural recording and manipulation has reinvigorated the study of this circuit and prompted re-examination of longstanding questions about the neural origins of thirst. Here, we review these advances, discuss what they teach us about the control of drinking behaviour and outline the key questions that remain unanswered.
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