期刊
NATURE REVIEWS NEUROSCIENCE
卷 18, 期 4, 页码 236-249出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2017.24
关键词
-
资金
- NINDS NIH HHS [R01 NS097016, R21 NS098385, R01 NS108750, R01 NS052669] Funding Source: Medline
NMDA receptors are preeminent neurotransmitter-gated channels in the CNS, which respond to glutamate in a manner that integrates multiple external and internal cues. They belong to the ionotropic glutamate receptor family and fulfil unique and crucial roles in neuronal development and function. These roles depend on characteristic response kinetics, which reflect the operation of the receptors. Here, we review biologically salient features of the NMDA receptor signal and its mechanistic origins. Knowledge of distinctive NMDA receptor biophysical properties, their structural determinants and physiological roles is necessary to understand the physiological and neurotoxic actions of glutamate and to design effective therapeutics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据