期刊
NATURE REVIEWS NEUROSCIENCE
卷 18, 期 11, 页码 658-670出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2017.110
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资金
- European Union's Horizon research and innovation programme [705452]
- International Brain Research Organization
- Lithuanian National Commission for the United Nations Educational, Scientific and Cultural Organization (UNESCO)
- Lithuanian Academy of Sciences
- LOREL Baltic For Women In Science fellowship
- Marie Curie Actions (MSCA) [705452] Funding Source: Marie Curie Actions (MSCA)
The final stage of brain development is associated with the generation and maturation of neuronal synapses. However, the same period is also associated with a peak in synapse elimination - a process known as synaptic pruning - that has been proposed to be crucial for the maturation of remaining synaptic connections. Recent studies have pointed to a key role for glial cells in synaptic pruning in various parts of the nervous system and have identified a set of critical signalling pathways between glia and neurons. At the same time, brain imaging and post-mortem anatomical studies suggest that insufficient or excessive synaptic pruning may underlie several neurodevelopmental disorders, including autism, schizophrenia and epilepsy. Here, we review current data on the cellular, physiological and molecular mechanisms of glial-cell-dependent synaptic pruning and outline their potential contribution to neurodevelopmental disorders.
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