期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 18, 期 7, 页码 452-465出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2017.22
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资金
- US National Institutes of Health [R01DK089098, R01DK102648, P01DK057751]
- American Cancer Society [RSG-14-244-01-TBE]
- State of Connecticut [DPH2014-0139]
- Ellison Medical Foundation
O-GlcNAcylation-the attachment of O-linked N-acetylglucosamine (O-GlcNAc) moieties to cytoplasmic, nuclear and mitochondrial proteins - is a post-translational modification that regulates fundamental cellular processes in metazoans. A single pair of enzymes - O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) - controls the dynamic cycling of this protein modification in a nutrient-and stress-responsive manner. Recent years have seen remarkable advances in our understanding of O-GlcNAcylation at levels that range from structural and molecular biology to cell signalling and gene regulation to physiology and disease. New mechanisms and functions of O-GlcNAcylation that are emerging from these recent developments enable us to begin constructing a unified conceptual framework through which the significance of this modification in cellular and organismal physiology can be understood.
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