期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 18, 期 3, 页码 141-158出版社
NATURE PORTFOLIO
DOI: 10.1038/nrm.2016.159
关键词
-
类别
资金
- Leukemia and Lymphoma Society
- STARR Foundation
- Memorial Sloan-Kettering Cancer Core Grant [P30 CA008748]
- European Research Council (ERC) [281765]
- Danish National Research Foundation [DNRF82]
- Danish Cancer Society
- Danish Medical Research Council
- Novo Nordisk Foundation
- Lundbeck Foundation
- European Research Council (ERC) [281765] Funding Source: European Research Council (ERC)
- Novo Nordisk Fonden [NNF14OC0012839] Funding Source: researchfish
The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal processes, including gene expression, chromosome segregation and genome replication and repair. Here, we review the distinct structural and functional properties of the expanding network of histone chaperones. We emphasize how chaperones cooperate in the histone chaperone network and via co-chaperone complexes to match histone supply with demand, thereby promoting proper nucleosome assembly and maintaining epigenetic information by recycling modified histones evicted from chromatin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据