期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 18, 期 11, 页码 671-684出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2017.76
关键词
-
类别
资金
- European Research Council ERC [340896]
- DKs Molecular Enzymology [W901]
- Metabolic and Cardiovascular Disease [W1226]
- SFB Lipotox [F30]
- Austrian Science Fund (FWF)
- Louis-Jeantet Foundation
- Fondation Leducq [12CVD04]
- BioTechMed-Graz flagship project EPIAge
- BioTechMed-Graz flagship project Lipid Signalling
- NAWI Graz
- BioTechMed-Graz (EPIAge)
- FWF [P29262, P29203, P27893]
- BMWFW
- University of Graz grant Unkonventionelle Forschung
- University of Graz grant Flysleep
- Austrian Science Fund (FWF) [P27070] Funding Source: Austrian Science Fund (FWF)
- European Research Council (ERC) [340896] Funding Source: European Research Council (ERC)
Fatty acids are the most efficient substrates for energy production in vertebrates and are essential components of the lipids that form biological membranes. Synthesis of triacylglycerols from non-esterified free fatty acids (FFAs) combined with triacylglycerol storage represents a highly efficient strategy to stockpile FFAs in cells and prevent FFA-induced lipotoxicity. Although essentially all vertebrate cells have some capacity to store and utilize triacylglycerols, white adipose tissue is by far the largest triacylglycerol depot and is uniquely able to supply FFAs to other tissues. The release of FFAs from triacylglycerols requires their enzymatic hydrolysis by a process called lipolysis. Recent discoveries thoroughly altered and extended our understanding of lipolysis. This Review discusses how cytosolic 'neutral' lipolysis and lipophagy, which utilizes 'acid' lipolysis in lysosomes, degrade cellular triacylglycerols as well as how these pathways communicate, how they affect lipid metabolism and energy homeostasis and how their dysfunction affects the pathogenesis of metabolic diseases. Answers to these questions will likely uncover novel strategies for the treatment of prevalent metabolic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据