期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 18, 期 8, 页码 517-527出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2017.35
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资金
- US National Institutes of Health [CA118487, GM117264, MH096066]
- Boston Children's Hospital
In 1959, while analysing the bacterial flagellar proteins, Ambler and Rees observed an unknown species of amino acid that they eventually identified as methylated lysine. Over half a century later, protein methylation is known to have a regulatory role in many essential cellular processes that range from gene transcription to signal transduction. However, the road to this now burgeoning research field was obstacle-ridden, not least because of the inconspicuous nature of the methyl mark itself. Here, we chronicle the milestone achievements and discuss the future of protein methylation research.
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