期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 18, 期 6, 页码 361-374出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2017.16
关键词
-
类别
资金
- UK Wolfson Foundation
- UK Medical Research Council (MRC) [MC_UU_12010/unit programmes G0902418, MC_UU_12025]
- MRC/BBSRC/ESPRC [MR/K01577X/1]
- UK Wellcome Trust [104924/14/Z/14]
- EMBO Long Term Fellowship [ALTF 636-2013]
- Marie Curie IntraEuropean Fellowship (MEMBRANE DYNAMICS)
- Department of Science and Technology, Ministry of Science and Technology, Government of India, New Delhi
- Margadarshi fellowship (DBT-Wellcome Trust Alliance grant) [IA/M/15/1/502018]
- Cancer Prevention and Research Institute of Texas [R1215]
- US National Institutes of Health [1R01GM114282]
- MRC [MR/K01577X/1, G0902418, MC_UU_00008/9, MC_UU_12010/9, MC_PC_16082] Funding Source: UKRI
- Medical Research Council [MR/K01577X/1, MC_UU_00008/9, MC_UU_12010/9, MC_PC_16082] Funding Source: researchfish
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the formation of relatively packed (or ordered) membrane domains that selectively recruit certain lipids and proteins. Recent studies have yielded new insights into this mechanism and its relevance in vivo, owing primarily to the development of improved biochemical and biophysical technologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据