期刊
NATURE REVIEWS MICROBIOLOGY
卷 15, 期 10, 页码 630-638出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro.2017.58
关键词
-
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [CRC1182 C2, CRC877 B9]
- Federal Ministry of Education and Research as part of the e:Med framework ('sysINFLAME') [01ZX1306]
- Cluster of Excellence 'Inflammation at Interfaces' [ExC 306]
- European Union [733100]
The composition of the intestinal microbiota varies among individuals and throughout development, and is dependent on host and environmental factors. However, although the microbiota is constantly exposed to environmental challenges, its composition and function in an individual are stable against perturbations, as microbial communities are resilient and resistant to change. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and also between the microorganisms and the intestinal interface of the host. The resilience of the healthy microbiota protects us from dysbiosis-related diseases, such as inflammatory bowel disease (IBD) or metabolic disorder. By contrast, a resilient dysbiotic microbiota may cause disease. In this Opinion article, we propose that microbial resilience has a key role in health and disease. We will discuss the concepts and mechanisms of microbial resilience against dietary, antibiotic or bacteriotherapy-induced perturbations and the implications for human health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据