期刊
NATURE REVIEWS MICROBIOLOGY
卷 16, 期 1, 页码 12-17出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro.2017.120
关键词
-
类别
资金
- Canadian Institutes of Health Research [MOP-130482, MOP-136845]
CRISPR-Cas adaptive immune systems are widespread among bacteria and archaea. Recent studies have shown that these systems have minimal long-term evolutionary effects in limiting horizontal gene transfer. This suggests that the ability to evade CRISPR-Cas immunity must also be widespread in phages and other mobile genetic elements. In this Progress article, we discuss recent discoveries that highlight how phages inactivate CRISPR-Cas systems by using anti-CRISPR proteins, and we outline evolutionary and biotechnological implications of their activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据