期刊
NATURE REVIEWS MICROBIOLOGY
卷 15, 期 3, 页码 149-159出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro.2016.178
关键词
-
类别
资金
- Fondation pour la Recherche Medicale
- French Agence Nationale de la Recherche
- INSERM (French Institut National de la Sante et de la Recherche Medicale)
- CNRS (French Centre National de la Recherche Scientifique)
- University Paris Descartes, France
The blood-brain barrier, which is one of the tightest barriers in the body, protects the brain from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria can cross the blood-brain barrier to cause meningitis. In this Review, we focus on invasive extracellular pathogens, such as Neisseria meningitidis, Streptococcus pneumoniae, group B Streptococcus and Escherichia coli, to review the obstacles that bacteria have to overcome in order to invade the meninges from the bloodstream, and the specific skills they have developed to bypass the blood-brain barrier. The medical importance of understanding how these barriers can be circumvented is underlined by the fact that we need to improve drug delivery into the brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据