期刊
NATURE REVIEWS GENETICS
卷 18, 期 5, 页码 292-308出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2017.7
关键词
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资金
- Fondation ARC pour la Recherche sur le Cancer (Projet Fondation ARC) [20141201838]
- Fondation pour la Recherche Medicale (FRM) [DEP20131128533]
- French Government (Agence Nationale Recherche (ANR)) through 'Investments for the Future' (LABEX SIGNALIFE) [ANR-11-LABX-0028-01]
- French Government (Agence Nationale Recherche (ANR)) through generic call project RETROMET [ANR-16-CE12-0020]
- Canceropole Provence-Alpes-Cote d'Azur (Projet Emergence)
- Centre National de la Recherche Scientifique (CNRS) [GDR 3546]
- University Hospital Federation (FHU) OncoAge
- Universite Cote d'Azur, France
- University of Dhaka, Bangladesh
- CNRS
- Universite Paris Diderot
- Institut National de la Sante et de la Recherche Medicale
- Canceropole Ile de France [2015-1 EMERG-24]
- Fondation ARC pour la Recherche sur le Cancer [PJA 20151203412]
- ANR through initiatives d'excellence [ANR-11-IDEX-0005-02, ANR11-LABX-0071]
- generic call project NiCiTy [ANR-13-BSV3-0012]
- Conservatoire National des Arts et Metiers, France
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV3-0012] Funding Source: Agence Nationale de la Recherche (ANR)
Transposable elements and retroviruses are found in most genomes, can be pathogenic and are widely used as gene-delivery and functional genomics tools. Exploring whether these genetic elements target specific genomic sites for integration and how this preference is achieved is crucial to our understanding of genome evolution, somatic genome plasticity in cancer and ageing, host-parasite interactions and genome engineering applications. High-throughput profiling of integration sites by next-generation sequencing, combined with large-scale genomic data mining and cellular or biochemical approaches, has revealed that the insertions are usually non-random. The DNA sequence, chromatin and nuclear context, and cellular proteins cooperate in guiding integration in eukaryotic genomes, leading to a remarkable diversity of insertion site distribution and evolutionary strategies.
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