期刊
NATURE REVIEWS GENETICS
卷 18, 期 6, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/nrg.2016.160
关键词
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资金
- John S. LaDue Memorial Fellowship in Cardiology
- KL2/Catalyst Medical Research Investigator Training award from Harvard Catalyst
- Ofer and Shelley Nemirovsky MGH Research Scholar Award
- US National Institutes of Health [HL127564, UM1HG008895]
Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology and informed the development of new therapeutics. Moving forwards, genetic testing could enable precision medicine approaches by identifying subgroups of patients at increased risk of coronary artery disease or those with a specific driving pathophysiology in whom a therapeutic or preventive approach would be most useful.
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