期刊
NATURE REVIEWS GENETICS
卷 18, 期 4, 页码 245-258出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2016.167
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资金
- National Human Genome Research Institute
- National Cancer Institute [1R01CA197139]
- National Institute of Mental Health [1R01MH109907]
- National Institute of Child Health and Human Development [1P01HD084387]
- National Institutes of Health, Office of the Director [1R21OD022988]
- National Science Foundation, Division of Environmental Biology [1442314]
- National Science Foundation, Division of Integrative Organismal Biology [1257873]
- Fulbright Research Scholar Program
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1257873] Funding Source: National Science Foundation
The limb is a commonly used model system for developmental biology. Given the need for precise control of complex signalling pathways to achieve proper patterning, the limb is also becoming a model system for gene regulation studies. Recent developments in genomic technologies have enabled the genome-wide identification of regulatory elements that control limb development, yielding insights into the determination of limb morphology and forelimb versus hindlimb identity. The modulation of regulatory interactions - for example, through the modification of regulatory sequences or chromatin architecture - can lead to morphological evolution, acquired regeneration capacity or limb malformations in diverse species, including humans.
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