期刊
NATURE REVIEWS DRUG DISCOVERY
卷 16, 期 7, 页码 487-511出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd.2017.22
关键词
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资金
- Department of Radiation Oncology of Weill Cornell Medical College
- Sotio a.c.
- French Ligue contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR)
- ANR
- European Research Area (ERA)-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Institut Universitaire de France
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- LeDucq Foundation
- LabEx Immuno-Oncology
- Site de Recherche Integree sur le Cancer (SIRIC) Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- National Institutes of Health
- Cancer Prevention Research Institute of Texas
- American Lebanese Syrian Associated Charities (ALSAC)
- Department of Radiation Oncology of Weill Cornell Medical College
- Sotio a.c.
- French Ligue contre le Cancer (equipe labellisee)
- Agence National de la Recherche (ANR)
- ANR
- European Research Area (ERA)-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Institut Universitaire de France
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- LeDucq Foundation
- LabEx Immuno-Oncology
- Site de Recherche Integree sur le Cancer (SIRIC) Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
- National Institutes of Health
- Cancer Prevention Research Institute of Texas
- American Lebanese Syrian Associated Charities (ALSAC)
Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.
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