期刊
NATURE REVIEWS CLINICAL ONCOLOGY
卷 15, 期 1, 页码 9-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2017.149
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资金
- US NIH [5UO1 AI124297, 5RO1 AG052608, 5R01 CA195712]
- US Department of Defense [W81XWH-17-1-0010]
The development of therapeutic cancer vaccines has been pursued for many decades. Many vaccines can elicit immunity to tumour antigens, although their clinical efficacy remains modest. Recent results from two clinical trials highlight the potential of personalized vaccination strategies, made possible by high-throughput approaches to the identification of immunogenic tumour neoantigens. Thus, therapeutic cancer vaccines might soon move into the mainstream.
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