期刊
GELS
卷 4, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/gels4020028
关键词
drug delivery; temperature responsive; gold nanoshell; hydrogel coating
资金
- Air Force Office of Scientific Research [AFOSR/AOARD FA2386-16-1-4067, FA2386-17-1-4028]
- Asian Office of Aerospace Research and Development [AFOSR/AOARD FA2386-16-1-4067, FA2386-17-1-4028]
- Robert A. Welch Foundation [E-1320]
- National Science Foundation [CHE-1411265, CHE-1710561]
- Texas Center for Superconductivity at the University of Houston
Gold nanoshells (similar to 160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at similar to 800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring.
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