期刊
ACS APPLIED NANO MATERIALS
卷 1, 期 7, 页码 3663-3672出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.8b00776
关键词
combined therapy; gold nanoparticles; photodynamic therapy; photothermal therapy; polyphosphazene nanospheres
资金
- Singapore Academic Research Fund [RG121/16, RG11/17, RG114/17]
- Singapore National Research Foundation Investigatorship [NRF-NRFI2018-03]
A rational combination of photodynamic therapy (PDT) and photothermal therapy (PTT) could achieve a synergistic therapeutic effect to enhance therapeutic efficacy in the cancer treatment. Herein, polyphosphazene nanospheres as a novel kind of photosensitizer carriers were synthesized by anchoring and isolating photosensitizing porphyrin monomers covalently in the cross-linked structure. Gold nanoparticles were then immobilized on the surface of the nanospheres to introduce the photothermal performance. The hybrid system was eventually conjugated by polyethylene glycol to decrease its cytotoxicity. The morphology analysis showed that the nanospheres were covered by homogeneously dispersed gold nanoparticles. In this way, the resulted system could afford efficient photodynamic and photothermal effect simultaneously, as confirmed by the cancer cell killing studies. The cell experiments demonstrated that the as-prepared polyphosphazene nanospheres with inherent fluorescence could be internalized by HeLa cells, showing high performance of combined PDT and PTT under suitable light irradiation. Thus, this integrated system presents its effectiveness to achieve combined PDT and PTT for enhanced cancer therapeutics.
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