期刊
NATURE NEUROSCIENCE
卷 20, 期 3, 页码 385-388出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4491
关键词
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资金
- European Research Council [260463]
- Israel Science Foundation [1565/15, 1916/12]
- Roberto and Renata Ruhman
- Bruno and Simone Licht
- Nella and Leon Benoziyo Center for Neurological Diseases
- Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics
- Perlman Family Foundation
- Adelis Foundation
- I-CORE Program of the Planning and Budgeting Committee
- Sarah and Rolando Uziel
- Irving I. Moskowitz Foundation
- Max Planck Society
- Weizmann Institute of Science
The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
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