期刊
NATURE NEUROSCIENCE
卷 20, 期 5, 页码 735-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4538
关键词
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资金
- Intramural Research Program at NIDA [ZIA-DA000587]
- [R01-MH098861]
- Intramural NIH HHS [ZIA DA000587-02, ZIA DA000587] Funding Source: Medline
- NIMH NIH HHS [R01 MH098861] Funding Source: Medline
Associative learning is driven by prediction errors. Dopamine transients correlate with these errors, which current interpretations limit to endowing cues with a scalar quantity reflecting the value of future rewards. We tested whether dopamine might act more broadly to support learning of an associative model of the environment. Using sensory preconditioning, we show that prediction errors underlying stimulus-stimulus learning can be blocked behaviorally and reinstated by optogenetically activating dopamine neurons. We further show that suppressing the firing of these neurons across the transition prevents normal stimulus-stimulus learning. These results establish that the acquisition of model-based information about transitions between nonrewarding events is also driven by prediction errors and that, contrary to existing canon, dopamine transients are both sufficient and necessary to support this type of learning. Our findings open new possibilities for how these biological signals might support associative learning in the mammalian brain in these and other contexts.
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