期刊
NATURE NEUROSCIENCE
卷 20, 期 9, 页码 1277-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4601
关键词
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资金
- Department of Veterans Affairs, Veterans Health Administration [VA Merit: 1I01RX001640, VA CDA 1IK2BX003308]
- National Institute of Neurological Disorders and Stroke [1K99NS097620, 5K02NS093014]
- American Heart/Stroke Association [15POST25510020]
- Burroughs Wellcome Fund [1009855]
- SFVAMC
- NCIRE
- UCSF Department of Neurology
A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this ` credit assignment' problem. Using neuroprosthetic learning, in which we could control the causal relationship between neurons and behavior, we found that sleep-dependent processing was required for credit assignment and the establishment of task-related functional connectivity reflecting the causal neuron-behavior relationship. Notably, we observed a strong link between the microstructure of sleep reactivations and credit assignment, with downscaling of non-causal activity. Decoupling of spiking to slow oscillations using optogenetic methods eliminated rescaling. Thus, our results suggest that coordinated firing during sleep is essential for establishing sparse activation patterns that reflect the causal neuron-behavior relationship.
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