期刊
NATURE NEUROSCIENCE
卷 20, 期 11, 页码 1591-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4645
关键词
-
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB1158]
- European Research Council (ERC) Advanced Investigator grants [294293, 230249]
- DFG via the Excellence Cluster CellNetworks (Ectop funding)
- European Molecular Biology Organization (EMBO)
- European Research Council (ERC) [294293, 230249] Funding Source: European Research Council (ERC)
The identity of cortical circuits mediating nociception and pain is largely unclear. The cingulate cortex is consistently activated during pain, but the functional specificity of cingulate divisions, the roles at distinct temporal phases of central plasticity and the underlying circuitry are unknown. Here we show in mice that the midcingulate division of the cingulate cortex (MCC) does not mediate acute pain sensation and pain affect, but gates sensory hypersensitivity by acting in a wide cortical and subcortical network. Within this complex network, we identified an afferent MCC-posterior insula pathway that can induce and maintain nociceptive hypersensitivity in the absence of conditioned peripheral noxious drive. This facilitation of nociception is brought about by recruitment of descendingserotonergic facilitatory projections to the spinal cord. These results have implications for our understanding of neuronal mechanisms facilitating the transition from acute to long-lasting pain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据