期刊
NATURE NEUROSCIENCE
卷 20, 期 3, 页码 393-395出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4492
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资金
- iMSE from GIST
- National Research Foundation of Korea [NRF:2013R1A2A2A01067890]
- Canadian Institutes of Health Research (CIHR) [MOP-11-51-31, MOP-142417]
- Alan Tiffin Foundation
- Alzheimer's Association [NIRG-08-92090]
- Fonds de la recherche en sante du Quebec
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- INCT for Excitotoxicity and Neuroprotection
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- department of Physiology, University of Lausanne
- National Research Foundation of Korea [2013R1A2A2A01067890] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [F-18]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [F-18]FDG signal.
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