期刊
NATURE NEUROSCIENCE
卷 21, 期 1, 页码 29-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-017-0023-y
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资金
- Francis Crick Institute
- Cancer Research UK
- UK Medical Research Council
- Wellcome Trust
- The Francis Crick Institute [10055] Funding Source: researchfish
Excitation of accumbal D2 cells governs vital actions, including avoidance of learned risks, but the origins of this excitation and roles of D2 cells in innate risk-avoidance are unclear. Hypothalamic neurons producing orexins (also called hypocretins) enhance innate risk-avoidance via poorly understood neurocircuits. We describe a direct orexin -> D2 excitatory circuit and show that D2 cell activity is necessary for orexin-dependent innate risk-avoidance in mice, thus revealing an unsuspected hypothalamus-accumbens interplay in action selection.
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