期刊
NATURE NEUROSCIENCE
卷 21, 期 1, 页码 130-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-017-0025-9
关键词
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资金
- Medical Research Council (Brain Bank) [MR/L016400/1]
- European Union Seventh Framework Programme [604102]
- Wellcome Trust for the Centre for Immunity, Infection and Evolution [095831/Z/11/Z]
- 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research
- McDonnell Center for Systems Neuroscience at Washington University
- Horizon 2020 [720270]
- Medical Research Council [MR/L016400/1, G0802238] Funding Source: researchfish
- MRC [G0802238, MR/L016400/1] Funding Source: UKRI
The postsynaptic proteome of excitatory synapses comprises similar to 1,000 highly conserved proteins that control the behavioral repertoire, and mutations disrupting their function cause >130 brain diseases. Here, we document the composition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, functional and structural magnetic resonance imaging, positron emission tomography imaging, and behavioral data. Neocortical regions show signatures of expression of individual proteins, protein complexes, biochemical and metabolic pathways. We characterized the compositional signatures in brain regions involved with language, emotion and memory functions. Integrating large-scale GWAS with regional proteome data identifies the same cortical region for smoking behavior as found with fMRI data. The neocortical postsynaptic proteome data resource can be used to link genetics to brain imaging and behavior, and to study the role of postsynaptic proteins in localization of brain functions.
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