期刊
NATURE NEUROSCIENCE
卷 20, 期 5, 页码 674-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4528
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/J01026X/1, BB/N003721/1]
- Leverhulme Trust [ECF-2014-390]
- QUB (QUB - Lucy McGuigan Bequest)
- UK Multiple Sclerosis Society [941, 50]
- MRC UK Regenerative Medicine platform [MR/KO26666/1]
- University of Edinburgh Wellcome Trust [WT104915MA]
- Wellcome Trust [097922/Z/11/Z, 110138/Z/15/Z]
- MRC [097922/Z/11/Z]
- Dept. for the Economy (Northern Ireland)
- British Pathological Society
- US National Multiple Sclerosis Society [RG5203A4]
- NIH/NINDS [NS095889]
- NIH/NIGMS [K12GM081266]
- BBSRC [BB/N003721/1, BB/J01026X/1] Funding Source: UKRI
- MRC [MR/K017047/1] Funding Source: UKRI
- Wellcome Trust [110138/Z/15/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/J01026X/1, BB/N003721/1] Funding Source: researchfish
- Medical Research Council [MR/K017047/1, MC_PC_12009] Funding Source: researchfish
- Rosetrees Trust [M144] Funding Source: researchfish
- Wellcome Trust [110138/Z/15/Z] Funding Source: researchfish
Regeneration of CNS myelin involves differentiation of oligodendrocytes from oligodendrocyte progenitor cells. In multiple sclerosis, remyelination can fail despite abundant oligodendrocyte progenitor cells, suggesting impairment of oligodendrocyte differentiation. T cells infiltrate the CNS in multiple sclerosis, yet little is known about T cell functions in remyelination. We report that regulatory T cells (T-reg) promote oligodendrocyte differentiation and (re) myelination. T-reg-deficient mice exhibited substantially impaired remyelination and oligodendrocyte differentiation, which was rescued by adoptive transfer of T-reg. In brain slice cultures, T-reg accelerated developmental myelination and remyelination, even in the absence of overt inflammation. T-reg directly promoted oligodendrocyte progenitor cell differentiation and myelination in vitro. We identified CCN3 as a T-reg-derived mediator of oligodendrocyte differentiation and myelination in vitro. These findings reveal a new regenerative function of T-reg in the CNS, distinct from immunomodulation. Although the cells were originally named 'T-reg' to reflect immunoregulatory roles, this also captures emerging, regenerative T-reg functions.
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