期刊
NATURE NANOTECHNOLOGY
卷 12, 期 5, 页码 460-466出版社
NATURE PORTFOLIO
DOI: 10.1038/NNANO.2017.3
关键词
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资金
- Catalyst foundation, Valhalla, New York
- Army Research Office [W911NF-15-1-0565]
- National Institutes of Health [1-U01-MH105960-01]
- Gordon and Betty Moore Foundation
- US Army Research Laboratory
- US Army Research Office [W911NF1510548]
Developing a new tool capable of high-precision electrophysiological recording of a large network of electrogenic cells has long been an outstanding challenge in neurobiology and cardiology. Here, we combine nanoscale intracellular electrodes with complementary metal-oxide-semiconductor (CMOS) integrated circuits to realize a high-fidelity all-electrical electrophysiological imager for parallel intracellular recording at the network level. Our CMOS nanoelectrode array has 1,024 recording/stimulation 'pixels' equipped with vertical nanoelectrodes, and can simultaneously record intracellular membrane potentials from hundreds of connected in vitro neonatal rat ventricular cardiomyocytes. We demonstrate that this network-level intracellular recording capability can be used to examine the effect of pharmaceuticals on the delicate dynamics of a cardiomyocyte network, thus opening up new opportunities in tissue-based pharmacological screening for cardiac and neuronal diseases as well as fundamental studies of electrogenic cells and their networks.
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